Correlation Between Serum beta 2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM

Objective: This study aims to study the correlation between serum beta 2-glycoprotein I (beta 2-GPI)/oxidized low-density lipoprotein (oxLDL) and the risk of cerebral infarction in patients with type 2 diabetes (T2DM). Methods: From January 2019 to March 2021, 56 patients with T2DM combined with cerebral infarction were chosen as a diabetic cerebral infarction (DCI) group, and 60 patients with simple T2DM were chosen as a T2DM group. In addition, 60 healthy volunteers were recruited as a control group. The essential information of each group was collected, and the serum beta 2-GPI/oxLDL and inflammatory factor levels in each group were compared. The clinical factors that affect the risk of ischemic cerebral infarction in patients with T2DM were analyzed by a logistic model. Results: Compared with the control group, the level of serum beta 2-GPI/oxLDL in the T2DM and DCI groups increased significantly, P < 0.001. Compared with the T2DM group, the serum beta 2-GPI/oxLDL level in the DCI group increased significantly, P < 0.05. The result of Pearson's correlation analysis showed that serum beta 2-GPI/oxLDL was positively correlated with total cholesterol, triglycerides, fasting blood glucose, 2-h postprandial blood glucose, glycosylated hemoglobin, interleukin-6, and tumor necrosis factor (TNF)-alpha (all P's < 0.05). Serum TNF-alpha and beta 2-GPI/oxLDL were independent risk variates for DCI (P < 0.05). Based on the receiver operating characteristic curve analysis, the values of the area under the curve for TNF-alpha, serum beta 2-GPI/oxLDL, and the combined diagnosis of DCI were 0.653 (0.552-0.753), 0.680 (0.583-0.777), 0.739 (0.647-0.831), respectively. Conclusion: In DCI patients, the levels of serum oxLDL/beta 2-GPI are significantly increased. Serum oxLDL/beta 2-GPI is an independent risk factor that affects the occurrence of DCI. In addition, the serum beta 2-GPI/oxLDL level implicates the lipid metabolism and inflammatory status of the internal environment of DCI patients to a certain extent.