Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway

Zhiwei Jie,Shiyu Wang,Qingliang Ma,Yang Shen,Xiangde Zhao,Hejun Yu,Ziang Xie,Chao Jiang

Journal of Bone Oncology（2022）

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摘要

•Pexmetinib inhibited osteoclastogenesis in vitro.•Pexmetinib inhibited breast cancer migration and invasion in vitro.•Pexmetinib treatment attenuated breast cancer induced osteolysis in vivo.

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关键词

P38 mitogen-activated protein kinase,Pexmetinib,Osteoclast,Breast cancer,Osteolysis

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