Oxidative stress and inflammation caused by 1-tetradecyl-3-methylimidazolium tetrafluoroborate in rat livers
Environmental science and pollution research international(2022)
摘要
The purpose of this study was to elucidate the mechanism underlying toxicity in the livers of male and female rats after treatment with 1-tetradecyl-3-methylimidazolium tetrafluoroborate ([C 14 mim]BF 4 , 0 [control], 12.5, 25, or 50 mg/kg) for 90 days. The results showed that [C 14 mim]BF 4 exposure led to a high level of ROS and MDA in rat livers and the lower expression of Nrf2 and its downstream related antioxidant proteins. In addition, the expression of NF-κB p65 and the levels of inflammatory cytokines were upregulated in exposure groups rats’ liver. After 30 days of cessation of exposure, the liver injury of rats in the 50 mg/kg exposure group was alleviated, and the above indicators were improved to varying degrees. The paper shows that [C 14 mim]BF 4 could damage rat liver through oxidative stress and inflammatory pathway.
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关键词
Ionic liquids,Rat,Hepatotoxicity,1-tetradecyl-3-methylimidazolium tetrafluoroborate,Oxidative stress,Inflammatory response
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