Targeting microglia–oligodendrocyte crosstalk in neurodegenerative and psychiatric disorders

•Microglia are resident macrophages of CNS that are involved in brain homeostasis.•Oligodendrocytes are myelinating cells of the CNS that metabolically support axons.•Microglia-oligodendroglia crosstalk is important in both health and disease.•Predicted ligand-receptor interactions are dysregulated in MS and MDD.•Ligand-receptor interactions between microglia and oligodendroglia are druggable.