Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein.

Zheng Yang,James Loy,Brian Poirson,Yanshan Dai,Surendran Rajendran,Shihua Xu,Vanessa Spires,Murali Gururajan,Zheng Lin,Jaren Arbanas,Stephen Carl,Samantha Pace,Yun Wang,John Mehl,Krishna Vasudevan, Thomas Spires, Ruslan Novosiadly, Shodeinde Coker, Raymond Perez, Kelly Covello,Paul Morin,Robert Graziano,Miranda Broz,Lois Lehman-McKeeman

Frontiers in Pharmacology（2022）

引用 1|浏览21

关键词

pharmacokinetic,pharmacodynamic modeling,Fc-fusion protein,IL-10,IL-18,therapeutic index,pharmacodynamic biomarker,anemia (therapy),thrombocytopenia (therapy)

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