Somatostatin Receptor-negative and Fluorodeoxyglucose-positron Emission Tomography-positive Lung Neuroendocrine Tumor G1 Exhibiting Cyclic Cushing's Syndrome

Localization of ectopic cyclic Cushing's syndrome, which causes life-threatening complications, is chal-lenging. A 70-year-old woman showed cyclic hypokalemia and hyperglycemia and was diagnosed with cyclic ectopic Cushing's syndrome. Although somatostatin-receptor scintigraphy failed to localize the responsible tu-mor, fluorodeoxyglucose-positron emission tomography (FDG-PET) showed the uptake of tracer in a lung tu-mor. Lobectomy resulted in remission. The resected adrenocorticotropic hormone (ACTH)-producing neuroendocrine tumor had Ki-67<2% and negative staining for somatostatin receptors. This is the first case assessed both radiological findings and pathological findings in cyclic ectopic Cushing's syndrome. Subse-quent FDG-PET is recommended if somatostatin-receptor scintigraphy is negative.