The characteristics and clinical relevance of tumor fusion burden in head and neck squamous cell carcinoma.

Lirui He,Dandan Ren,Guoqing Lv,Beibei Mao,Lijia Wu,Xiaoyu Liu,Longlong Gong,Ping Liu

CANCER MEDICINE（2023）

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摘要

Our data revealed the correlation of TFB with tumor immune microenvironment and predictive features for immunotherapy, implying tumors with low TFB may be potential candidates for immunotherapeutic agents. Moreover, the TFB low group had prolonged overall survival (OS) in the HPV (-) HNSC cohort.

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关键词

head and neck squamous cell carcinoma,human papillomavirus,immune infiltration,tumor fusion burden

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