The Interactive Role of Macrophages in Innate Immunity

Macrophages are critical effector cells of the innate immune system that play central roles in the initiation and resolution of inflammation. They mediate resistance in response to pathogens and “danger” signals mainly through phagocytosis. Macrophages and other cells co-operate and complement one another in host defense. As innate immune cells, they also contribute to the initiation of adaptive immune responses. Therefore, appropriate activation of macrophages would aid effective immune response in curbing many infections. This chapter explores how the interaction and roles of macrophages influence outcomes during infections. It is expected that understanding these fundamental mechanisms may help stimulate research to exploit macrophages for therapeutic benefits.