Evaluation of Anti-granulation effect of Apigenin-A plant Flavonoid in Wister Albino Rat

Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The antiinflammatory activity of Apigenin (10, 20 and 40 mg/kg p.o) has been evaluated in cotton pellet-induced granuloma in Wister albino rats. Apigenin has reduced inflammation as evidenced by decreased weight of cotton pellet in cotton pellet-induced granuloma in rats. The optimal anti-inflammatory effect of apigenin can be seen at dose 20mg/Kg in cotton pellet-induced granuloma model (P<0.001) in comparison to control and respective group. The results demonstrate the anti-inflammatory properties of Apigenin and the effects were comparable to diclofenac sodium, a standard non-steroidal anti-inflammatory drug.