IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via IκBζ-dependent induction of ELF3.

Vesa-Petteri Kouri,Juri Olkkonen,Katariina Nurmi,Nitai Peled,Mari Ainola,Jami Mandelin,Dan C Nordström,Kari K Eklund

Rheumatology (Oxford, England)（2023）

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摘要

Altogether, our results establish ELF3 as an important mediator of the synergistic effect of IL-17A and TNF in synovial fibroblasts. The findings provide novel information of the pathogenic mechanisms of IL-17A in chronic arthritis and implicate ELF3 as a potential therapeutic target.

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关键词

ELF3,IL-17A,TNF,fibroblasts,inflammation,synovial

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