Excessive IL-10 and IL-18 trigger hemophagocytic lymphohistiocytosis–like hyperinflammation and enhanced myelopoiesis

Journal of Allergy and Clinical Immunology（2022）

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摘要

Coelevated IL-10 and IL-18 are sufficient to drive HLH-like hyperinflammatory syndrome, and blocking IL-10 is protective in HLH models.

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关键词

IL-10,IL-18,hyperinflammation,HLH,macrophage polarization,myelopoiesis,cytokine storm

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