Comparison of the somatic mutations between circulating tumor DNA and tissue DNA in Chinese patients with non-small cell lung cancer.

Meng Zhang,Yi Feng,Changda Qu, Meizhu Meng,Wenmei Li,Meiying Ye,Sisi Li,Shaolei Li,Yuanyuan Ma,Nan Wu,Shuqin Jia

The International journal of biological markers（2022）

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摘要

Advanced-stage, treatment naïve or poor therapy outcome, and large tumor size were associated with a high concordance and detection rate. Patients with detectable mutations in ctDNA had a higher level of carcinoembryonic antigen, CA125, NSE, and CYFRA21-1.

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关键词

NSCLC,biomarker,concordance,ctDNA,liquid biopsy

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