High-Grade Chondrosarcoma of the Larynx with Multiple Metastases: Case Report and Literature Review

Chondrosarcoma (CS) is a rare laryngeal malignancy of indolent course. The high-grade CS (HGCS) represents the rarest and the most aggressive type. We present the case of a male patient with a cricoid cartilage HGCS with extralaryngeal invasion and thyroid gland metastases. Three years after hemilaryngectomy and radiotherapy, the patient developed local recurrence treated with salvage laryngectomy. In each of the consecutive years our patient developed new regional and distant metastases in the tracheal stoma, anterior chest wall, lung and clavicle, which were treated surgically when possible or with radiotherapy. After 8 years the patient died with the disease, confirming the slow progression of this high-grade malignancy. The treatment for HGCS is total laryngectomy. This tumour is associated with a poor prognosis. Long term follow up is necessary. Our case is unique by the multitude of loco-regional and distant metastases and the 2 courses of radiotherapy received.