Hyaluronic acid-poly(lactic-co-glycolic acid) nanoparticles with a ruthenium photosensitizer cargo for photokilling of oral cancer cells

jose Quilez Alburquerque,Mohammad Ahsan Saad,Ana B. Descalzo,Guillermo Orellana,Tayyaba Hasan

Journal of Photochemistry and Photobiology A: Chemistry（2023）

引用 2|浏览6

暂无评分

摘要

•Enhanced photodynamic effect by Ru(II) complex through both Type I and II mechanisms.•Synthesis of Ru(II) complex with 2,2′-biimidazole for PDT of oral cancer.•Ru(II) complex encapsulation in HA-PLGA NPs for improved solubility and selectivity.•High intracellular uptake of Ru(II) complex mediated by HA targeting of CD44.•Preferential accumulation of Ru(II) complex in the mitochondria.

查看译文

关键词

Photodynamic therapy,Ru(II) complex,Hyaluronic acid-poly(lactic-co-glycolic acid),Superoxide anion

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要