Association Analysis of Polymorphism of FGFR1 and EBP41L5 Genes with Kidding Performance of Goats

This study aimed to analyze the association between single nucleotide polymorphisms (SNPs) in the FGFR1 and EBP41L5 genes and kidding performance of goats. Mass ARRAY (R) SNP typing technology was applied to genotype the SNPs of FGFR1 and EBP41L5 genes, of which the genetic characteristics of Yunshang Black goat (YS, n=544), Jining Grey goat (JN, n=133) and Liaoning Cashmere goat (LN, n=91) were explored. Then the association was analyzed between FGFR1 and EBP41L5 and kidding performance (litter size, litter weight at birth, litter weight at weaning) in different goats. Population genetics statistics showed that FGFR1 gene g. 12120297A> G and EPB41L5 gene g. 64237881A> were low polymorphisms in the three populations (PIC< 0.25); EPB41L5 gene g. 64266710G> C and g. 64266715G> C were moderately polymorphic in Yunshang Black goat and Liaoning Cashmere goat (0.25 C locus was under Hardy-Weinberg disequilibrium in Jining grey goat (P< 0.05), and was under Hardy-Weinberg equilibrium in Yunshang Black goat and Liaoning Cashmere goat (P> 0.05). FGFR1 gene g. 12120297A> G, EPB41L5 gene g. 64266710G> C, g. 64266715G> C were under Hardy-Weinberg equilibrium in Yunshang Black goat, Jining Grey goat and Liaoning Cashmere goat (P> 0.05). Association analysis indicated that there were no significant correlation between FGFR1 gene g. 12120297A> G locus and EPB41L5 gene g. 64266715G> C locus and litter size, litter weight birth and weaning (P> 0.05). There were significant correlation between EPB41L5 gene g. 64237881A> C and g. 64266710 G> C and litter size (P< 0.05), and were no significant correlation and litter weight birth (P> 0.05), there were no significant correlation between EPB41L5 gene g. 64237881A> C and litter weight at weaning (P> 0.05), there were significant correlation between EPB41L5 gene g. 64266710C> G and litter weight at weaning (P< 0.05). Therefore, these results suggested that EPB41L5 gene 64237881A> C, g. 64266710 G> C loci were suitable as molecular markers for litter size in YS, and 64266710G> C locus was suitable as a selection marker for litter weight at weaning.