Inhibition of BET Protein Function Suppressed the Overactivation of the Canonical NF-κB Signaling Pathway in 6-OHDA-Lesioned Rat Model of Levodopa-Induced Dyskinesia.

Ying Wan,Li Han, Lu Rong,Shuyuan Yang,Lu Song,Na Wu,Zhenguo Liu,Jing Gan

Frontiers in neuroscience（2022）

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摘要

L-dopa triggered an overactivation of the canonical NF-κB signaling pathway, leading to an enhanced neuroinflammation response in the 6-OHDA-lesioned striatum of LID rat models. The inhibition of the BET protein function significantly suppressed the activation of the canonical NF-κB signaling pathway in the striatum, alleviating the neuroinflammation response and the severity of LID.

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关键词

NF-κB signaling,inhibition of BET protein function,intervention,levodopa induced dyskinesia,neuroinflammation

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