Characteristics of and Treatment Strategies for Advanced EGFR-Mutant NSCLC With Concomitant BRAF Variations

Xue-Wu Wei,Jia-Yi Deng,Chong-Rui Xu,Zhi-Hong Chen,Dong-Qin Zhu, Qian Wu,Xu-Chao Zhang,Yi-Long Wu,Qing Zhou

JTO Clinical and Research Reports（2022）

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摘要

Variations in the downstream and bypass pathways were frequent in patients with dual mutations of and . The efficacies of TKIs not targeting both EGFR and BRAF were inferior to chemotherapy. EGFR plus BRAF co-inhibition improved efficacy. Such treatment strategies should be further explored.

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关键词

BRAF,EGFR,NSCLC,Characteristics,Treatment strategy

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