A Conceptual Framework for Life-Cycle Health Technology Assessment

•We propose the life-cycle (LC)-health technology assessment (HTA) framework to address 3 challenges faced under standard HTA: (1) health system sustainability, (2) evolving evidence, and (3) uncertainty.•The LC-HTA framework is built around on-market evidence generation and risk-based pricing strategies. Where decision uncertainty exists, we recommend risk-based pricing and research-oriented managed access. Contractual procurement agreements define the terms of reassessment and provide additional decision options to HTA agencies. LC-HTA extends value-of-information methods to inform research-oriented managed access agreements, leveraging routine, administrative data, and registries to reduce uncertainty.•There are 6 stages to LC-HTA: (1) preassessment, (2) safety and efficacy assessment, (3) HTA, (4) adoption, (5) deadoption, and (6) reassessment. These stages are sequenced to minimize analytic time while optimizing decision certainty. The use of this framework could improve outcomes for patients, sponsors, and payers.