Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development

Marina Serra,Mario Di Matteo,Jens Serneels,Rajesh Pal,Sarah Trusso Cafarello,Martina Lanza,Carlos Sanchez-Martin,Matthias Evert,Alessandra Castegna,Diego Francesco Calvisi,Massimiliano Mazzone,Amedeo Columbano

Cellular and Molecular Gastroenterology and Hepatology（2022）

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摘要

These results demonstrate that Ldha deletion significantly impairs mouse HCC development and suggest lactate dehydrogenase as a potential target to enhance the efficacy of the current therapeutic options.

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关键词

HCC,c-Myc,Ldha,Metabolic Reprogramming,TME

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