Computer-assisted in vitro reconstitution of purine degradation pathway to lower the purine content in food.

Ping Shi,Ran Zhang, Chen-Xing Liu,Shun-Xin Wu,Xiao-Dong Pei,Yi Jiang,Xiao-Ling Liu,Cheng-Hua Wang

Journal of the science of food and agriculture（2022）

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摘要

This is the first in vitro reconstitution of complete purine metabolic pathway by combining ANN and GA technologies, with successful application with respect to lowering the purine content in food, indicating a promising application of computer-assisted in vitro reconstitution of purinolytic pathway in low-purine food to prevent hyperuricemia and gout. © 2022 Society of Chemical Industry.

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关键词

BP neural network,genetic algorithm,in vitro reconstruction,purine degrading enzymes,purine metabolic pathway

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