Metabolomics and biochemical insights on the regulation of aging-related diabetes by a low-molecular-weight polysaccharide from green microalga Chlorella pyrenoidosa

Yinghui Qiu,Xiaoxiang Gao,Ruoxin Chen,Suyue Lu,Xuzhi Wan,Mohamed A Farag,Chao Zhao

Food Chemistry: X（2022）

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摘要

•C. pyrenoidosa polysaccharide (CPP) have hypoglycemic activity and oxidation resistance.•CPP prevents oxidative stress and stimulates insulin via affecting phenylpyruvic acid.•CPP can regulate the GLP-1R/IL-6R and ZO-1/MMP-2 pathways.•CPP activated BCL-6 to promote cell survival in brain.

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关键词

Chlorella pyrenoidosa polysaccharide,Metabolomics,Type 2 diabetes,Antioxidant,Phenylpyruvic acid

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