Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for the suppression of multiple myeloma cell growth.

Jianxin Huo,Yuhan Huang,Ziying Zheng, Xin Ni Tay,Farouq Bin Mahfut,Wei Zhang,Kong-Peng Lam,Yuansheng Yang,Shengli Xu

Antibody therapeutics（2022）

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摘要

Our results suggest that the BCMA × CD3 bsAb in the FabscFv format can efficiently inhibit MM cell growth and have promising potential to be developed into a therapeutic antibody drug for the treatment of MM.

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关键词

BCMA,bispecific antibody,multiple myeloma,therapeutic

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