Cardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis

Elvira D'Andrea,Rishi J Desai,Mengdong He,Robert J Glynn,Hemin Lee,Michael E Weinblatt,Seoyoung C Kim

Journal of the American College of Cardiology（2022）

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摘要

In older patients with rheumatoid arthritis, hydroxychloroquine and methotrexate showed similar SCA/VA and MACE risks; however, hydroxychloroquine initiators with history of HF had higher risks of MACE, cardiovascular mortality, all-cause mortality, and myocardial infarction. An increased hospitalized HF risk was observed among hydroxychloroquine initiators regardless of an HF history.

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关键词

administrative data,cardiovascular,disease-modifying antirheumatic drugs (DMARDs),pharmacoepidemiology,rheumatoid arthritis

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