Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever

Rosângela Salerno-Gonçalves,Stephanie Fresnay,Laurence Magder,Thomas C Darton,Claire S Waddington,Christoph J Blohmke,Brian Angus,Myron M Levine,Andrew J Pollard,Marcelo B Sztein

Cellular Immunology（2022）

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摘要

•First demonstration of cytokine-secreting MAIT cell kinetics after human challenge with Salmonella enterica serovar Typhi.•MAIT cell's functional signatures and association with typhoid fever protection.•Predictive value of MAIT cell cytokine pattern.•Lack of association between the number of cytokines expressed by MAIT cells and prevention against typhoid fever.

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关键词

MAIT cells,Human,Polyfunctionality,Disease status,Bacteria,Salmonella

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