Correlations between objective response rate and survival-based endpoints in first-line advanced non-small cell lung Cancer: A systematic review and meta-analysis

•Objective response rate (ORR) was statistically associated with overall survival (OS) in a trial-level meta-analysis.•The trial-level relationship between OS and ORR was stronger in immunotherapy-based compared to chemotherapy-only trials.•For a given ORR benefit, OS gains were significantly larger with immunotherapy-based compared to chemotherapy-only trials.