POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC

Marina K Baine,Christopher A Febres-Aldana,Jason C Chang,Achim A Jungbluth,Shenon Sethi,Cristina R Antonescu,William D Travis,Min-Shu Hsieh,Mee Sook Roh,Robert J Homer,Marc Ladanyi,Jacklynn V Egger,W Victoria Lai,Charles M Rudin,Natasha Rekhtman

Journal of Thoracic Oncology（2022）

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摘要

This is the largest cohort of SCLC-P clinical samples to date, where we describe the diagnostic utility of POU2F3 in a challenging subset of SCLC with low or absent expression of standard neuroendocrine markers. The distinct genomic alterations in SCLC-P may offer a novel avenue for therapeutic targeting. The role of POU2F3 in a narrow subset of other lung cancer types warrants further study.

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关键词

POU2F3,Small cell lung carcinoma,SCLC-P,Neuroendocrine-low

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