The association between clinical and biological characteristics of depression and structural brain alterations

Yara J Toenders,Lianne Schmaal,Laura Nawijn,Laura K M Han,Julia Binnewies,Nic J A van der Wee,Marie-Jose van Tol,Dick J Veltman,Yuri Milaneschi,Femke Lamers,Brenda W J H Penninx

Journal of Affective Disorders（2022）

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摘要

•Depression severity was associated with a thinner rostral anterior cingulate cortex (ACC)•Melancholic depressive symptoms were negatively associated with caudal ACC thickness•No associations between immuno-metabolic dysregulation and structural brain alterations were found•Immuno-metabolic dysregulation and brain structure might be distinct mechanisms, although both associated with depression

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关键词

Major depressive disorder,Inflammation,Metabolic dysregulation,Brain structure

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