New dihydrobenzoxanthone derivatives with bacterial neuraminidase inhibitory activity isolated from Artocarpus elasticus

Bioorganic chemistry(2022)

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摘要
•Investigation of A. elasticus lead to new dihydrobenzoxanthones inhibiting BNA.•Eight compounds, including two new, were characterized by spectroscopic methods.•Kinetic parameters determined by Michaelis-Menten equation double reciprocal plots.•Binding affinities between the BNA and compounds were measured by FS quenching.•The binding site was found by molecular docking experiments.
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关键词
Artocarpus elasticus,Dihydrobenzoxanthone,Bacterial neuraminidase
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