Recent Progress of Peptide-based Drug Delivery System

Drug delivery system is a system to deliver drugs to targets. An ideal delivery system can improve drug efficacy and reduce drug dosage, toxicity and side effects. This paper reviews the research progress of peptide-based drug delivery systems. Polypeptide (peptide) has the advantages of facile synthesis, easy metabolism, low immunogenicity, low toxicity and side effects. In addition, there are a large number of functional groups on the peptide branch chain, which can be coupled with drugs. Therefore, peptide-based drug delivery system has become an important development direction of drug delivery system, which is introduced from four aspects: targeting peptides, penetrating peptides, response peptides and assembling peptides with the examples and principles. Assembling peptides form nanostructures and enhance the stability of drug delivery system for long-term release. In vivo modulation of assembly behavior of peptides increased the intelligence and precise, showing great potential in clinical translation of drug delivery system.