Pathogenesis of Brucella ovis in pregnant mice and protection induced by the candidate vaccine strain B. Ovis ΔabcBA

Heloísia Maria Bressan Braz,Monique Ferreira Silva,Thaynara Parente de Carvalho,Laice Alves da Silva, Jefferson Bruno Soares,Fabíola Barroso Costa,Brunno Gardiman Sossai,Tatiane Alves da Paixão,Renato Lima Santos

Vaccine（2022）

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摘要

•Brucella ovis is a suitable model for Brucella-induced fetal and placental lesions.•The candidate vaccine strain B.ovis ΔabcBA is safe for pregnant mice.•B.ovis ΔabcBA has protective potential in pregnant mice against virulent B.ovis.

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关键词

Transplacental pathogenicity,Vaccine,Brucella ovis,Pregnant,Necrotizing placentitis

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