Chimeric transcripts observed in non-canonical FGFR2 fusions with partner genes' breakpoint located in intergenic region in intrahepatic cholangiocarcinoma

Lei Yin, Zhijun Han, Meilin Feng,Jie Wang,Zhenghua Xie,Wenlong Yu,Xiaohui Fu,Ningjia Shen,Xiang Wang,Anqi Duan,Yongjie Zhang,Jing Ma

Cancer Genetics（2022）

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摘要

•Four gene-intergenic FGF2 fusions were identified in 493 ICC samples.•The four non-canonical FGFR2 fusions can generate chimeric transcript.•The transcripts were characterized by exon17 of 5′ FGFR2 fusing with the exon2 of 3′ partner.•Combined with RNA-NGS, it may make up for omissions caused by DNA-NGS.

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关键词

FGFR2 fusion,Breakpoint,Gene-intergenic,NGS,Intrahepatic cholangiocarcinoma

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