Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.

Rashmi Chandra,Dipendra K Aryal,Jonathan D Douros,Rafiq Shahid, Supriya J Davis,Jonathan E Campbell,Olga Ilkayeya,Phillip J White,Ramona Rodriguez,Christopher B Newgard,William C Wetsel,Rodger A Liddle

PloS one（2022）

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摘要

Ildr1 loss significantly modified metabolic activity in these mutant mice. While Ildr1 gene deletion increased high fat food intake, it reduced weight gain and improved glucose tolerance. These findings indicate that ILDR1 modulates metabolic responses to feeding in mice.

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