A Combination of MTAP and p16 Immunohistochemistry Can Substitute for CDKN2A Fluorescence In Situ Hybridization in Diagnosis and Prognosis of Pleural Mesotheliomas.

Luka Brcic,Nolwenn Le Stang,Florian Gallob,Daniel Pissaloux,Ruth Sequeiros,Sandrine Paindavoine,Jean Claude Pairon,Marie Karanian,Sanja Dacic,Nicolas Girard,Andrew Churg,Franck Tirode,Francoise Galateau-Salle

Archives of pathology & laboratory medicine（2023）

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摘要

MTAP immunohistochemical staining is a valid surrogate marker for CDKN2A HD by FISH; however, to obtain the same accuracy as the FISH assay, a combination of nuclear p16 and cytoplasmic MTAP staining is recommended. These findings correlate with prognosis.

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pleural mesotheliomas,immunohistochemistry

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