Multiplexed quantification of insulin and C-peptide by LC-MS/MS without the use of antibodies

North Foulon, Elisha Goonatilleke,Michael J MacCoss,Michelle A Emrick,Andrew N Hoofnagle

Journal of Mass Spectrometry and Advances in the Clinical Lab（2022）

引用 3|浏览2

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摘要

•Simultaneous quantification of insulin and C-peptide without antibodies.•Proteolysis with Glu-C permits sensitive and precise measurements.•Calibration with certified reference material provides traceability.•Relatively large bias when compared with a commercially available immunoassay.

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关键词

LC-MS/MS,LLOQ,TaMADOR

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