Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling

Zhaohua Guo,Jintao Zhang,Xuemei Liu,Jacqueline Unsinger,Richard S Hotchkiss,Yu-Qing Cao

Neurobiology of Pain（2022）

引用 5|浏览8

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摘要

•Low-dose interleukin-2 treatment increases the levels of cytokine IL-10 and TGFβ1.•Peripheral IL-10 and TGFβ1 signaling mediate the therapeutic effects of interleukin-2.•IL-10 and TGFβ1 directly reverses chronic migraine-related peripheral sensitization.

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关键词

Chronic migraine,Sensitization,Low-dose interleukin-2,Transforming growth factor beta-1,Interleukin-10,Trigeminal ganglion neuron

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