LATE SKIN FIBROSIS IN SYSTEMIC SCLEROSIS: A STUDY FROM THE EUSTAR COHORT

Michael Hughes,Suiyuan Huang,Juan Jose Alegre-Sancho,Patricia E Carreira,Merete Engelhart,Eric Hachulla,Joerg Henes,Eduardo Kerzberg,Maria Rosa Pozzi,Gabriela Riemekasten,Vanessa Smith,Gabriella Szücs,Marie Vanthuyne,Elisabetta Zanatta,Oliver Distler,Armando G Gabrielli,Anna-Maria Hoffmann-Vold,Virginia D Steen,Dinesh Khanna

ANNALS OF THE RHEUMATIC DISEASES（2022）

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摘要

Late skin fibrosis is not uncommon in SSc. We have identified different patterns relevant to clinical practice and trial design. Late skin fibrosis is a neglected manifestation of SSc and warrants further investigation including to determine clinical outcomes and optimal therapeutic strategy.

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关键词

Clinical trial design,Cohort enrichment,Fibrosis,Late disease,Scleroderma,Skin,Systemic sclerosis

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