Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies.

Lucile Figueres, Sarah Bruneau,Caroline Prot-Bertoye,Gaëlle Brideau, Mélanie Néel,Camille Griveau,Lydie Cheval,Yohan Bignon,Jordan Dimitrov,Thomas Dejoie,Simon Ville,Christine Kandel-Aznar,Anne Moreau,Pascal Houillier,Fadi Fakhouri

Journal of the American Society of Nephrology : JASN（2022）

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摘要

Pathogenic claudin-16 autoantibodies represent a novel autoimmune cause of specific renal tubular transport disturbances and tubulointerstitial nephropathy. Screening for autoantibodies targeting claudin-16, and potentially other magnesium transporters or channels in the kidney, may be warranted in patients with acquired unexplained hypomagnesemia.

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关键词

autoantibodies,claudin-16,hypocalcemia,hypomagnesemia

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