Suppression of tumor progression by thioredoxin-interacting protein-dependent adenosine 2B receptor degradation in a PLAG-treated Lewis lung carcinoma-1 model of non–small cell lung cancer

Guen Tae Kim,Eun Young Kim,Su-Hyun Shin,Hyowon Lee,Se Hee Lee,Ki-Young Sohn,Jae Wha Kim

Neoplasia（2022）

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摘要

•PLAG effectively inhibited excessive growth of LLC1 cells in an NSCLC model.•PLAG inhibited tumor growth by inducing adenosine 2B receptor (A2BR) degradation.•Unlike antagonists, PLAG terminates rather than suppresses signaling pathways.•A2BR degradation by PLAG occurs through expression and re-localization of TXNIP.

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关键词

1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG),Thioredoxin-interacting protein,Adenosine 2B receptors,Degradation,Signal termination

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