Lynch syndrome and breast cancer

Spyridon Marinopoulos, Eftychia Papachatzopoulou,Dimitrios Maniatis,Ioannis Papapanagiotou, Aris Giannos,Constantine Dimitrakakis

Ejso（2022）

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摘要

Introduction: Lynch Syndrome (LS) is a hereditary cancer predisposition syndrome caused by autosomal dominant mutation in tumour suppressor genes, the DNA mismatch repair proteins (MMR). Alterations in four genes are related to LS: MLH1, MSH2, MSH6 and PMS2. Is associated with a variety of cancers, mostly colorectal and endometrial. We present three cases of breast cancer (BC) associated with LS.

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lynch syndrome,breast cancer

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