Cytotoxic activity of nitrogen, sulfur, and oxygen chelated Pt(II) complexes; their DNA/BSA binding by in vitro and in silico approaches

Rituparna Bhaduri,Saikat Mandal,Swarup Kumar Tarai,Angana Pan, Subhajit Mukherjee,Arka Bagchi,Arunima Biswas,Sankar Ch. Moi

Journal of Molecular Liquids（2022）

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摘要

Bioactivity of synthesized Pt(II) complexes have been explored by In vitro and In silico approaches. The complexes exhibit promising cytotoxic profile compared to recognized anticancer drugs.

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关键词

BSA,CBDCA,CT-DNA,DFT,DMEM,DMSO,ESI,EtBr,FBS,FT-IR,GSH,H2DCFDA,HSA,IC50,LC,MEP,MTT,NAC,NBO,NMR,ox,PBS,PDB,PEA,PI,ROS,TBE,TD-DFT

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