Chelerythrine ameliorates rheumatoid arthritis by modulating the AMPK/mTOR/ULK-1 signaling pathway

Jun Cai, Lu-Chen Zhang, Ren-Jie Zhao, Li-Min Pu,Ke-Yuan Chen,Ali Adnan Nasim,Elaine Lai-Han Leung,Xing-Xing Fan

Phytomedicine（2022）

引用 8|浏览4

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摘要

•Chelerythrine suppressed inflammation in rheumatoid arthritis in vitro and in vivo.•Chelerythrine induced cell death of HFLS-RA cells through activating the AMPK/mTOR/ULK-1 signaling pathway.•Chelerythrine is a potential therapeutic candidate for the prevention and treatment of rheumatoid arthritis.

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关键词

Chelerythrine,Rheumatoid arthritis,AMPK/mTOR/ULK-1,Apoptosis,Autophagy

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