Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy.

Nina Zippel,Cynthia Hess Kenny,Helen Wu,Michel Garneau,Rachel Kroe-Barrett,Priyanka Gupta,Sarah Low,Remko A Bakker,Leo Thomas

Translational vision science & technology（2022）

引用 7|浏览8

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摘要

BI-X is a potent inhibitor of human Sema3A that improves revascularization in a murine model of OIR; BI-X is currently being investigated in patients with laser-treated PDR and DMI.

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关键词

avascular area, diabetic macular ischemia, diabetic retinopathy, semaphorin 3A, tip cell density

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