NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis

Zhuo Wang,Yina Li,Yingze Ye,Hua Zhu,Jing Zhang,Huijuan Wang,Jiaxi Lei,Lijuan Gu,Liying Zhan

Brain Research Bulletin（2022）

引用 9|浏览5

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摘要

•NLRP3 deficiency ameliorates neurological deficits and reduces the infarct volume after MCAO.•NLRP3 deficiency reduces OS and inflammation in mice after MCAO.•NLRP3 deficiency inhibits ferroptosis in mice after MCAO and in BV2 cells after OGD/R.•NLRP3 deficiency inhibits ferroptosis and OS may through down-regulating Keap1-Nrf2 signal pathway.

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关键词

NLRP3,Ferroptosis,Keap1/Nrf2 signalling pathway,Cerebral ischemia-reperfusion injury (CIRI),Inflammation

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