Intraoperative opioids are associated with decreased recurrence rates in colon adenocarcinoma: a retrospective observational cohort study

Jonathan B Yuval,Jasme Lee,Fan Wu,Hannah M Thompson,Floris S Verheij,Hersh V Gupta,Takeshi Irie,Joseph R Scarpa,Patrick J McCormick,J Joshua Smith,Jinru Shia,Martin R Weiser,Francisco Sánchez-Vega,Kay See Tan,Gregory W Fischer,Julio Garcia-Aguilar,Joshua S Mincer

British Journal of Anaesthesia（2022）

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摘要

Higher intraoperative opioid dose was associated with a lower risk of tumour recurrence after surgery for stage I-III colon adenocarcinoma, but particularly so in tumours in which DNA MMR was deficient.

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关键词

colon adenocarcinoma,DNA mismatch repair,gene expression,immunomodulation,opioids,surgery

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