An unprecedented ergostane with a 6/6/5 tricyclic 13(14 → 8)abeo-8,14-seco skeleton from Talaromyces adpressus

Mi Zhang,Qin Li,Shuangjun Li,Yanfang Deng,Muyuan Yu,Jinping Liu,Changxing Qi,Xiliang Yang,Hucheng Zhu,Yonghui Zhang

Bioorganic Chemistry（2022）

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摘要

•An unprecedented 6/6/5 tricyclic 13(14 → 8)abeo-8,14-seco-ergostane steroid was characterized from Talaromyces adpressus.•The structure of 1 with absolute configuration was elucidated based on NMR spectroscopic data and ECD calculation.•Compound 1 exhibited potent anti-inflammatory activity with IC50 value of 8.73 ± 0.66 μM.

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关键词

Rearranged steroid,Talaromyces adpressus,Dankasterone,Anti-inflammatory activity,NF-κB pathway

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