Integration of Sequencing and Epidemiologic Data for Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections in a Tertiary-Care Hospital.

Manja Czech-Sioli,Thomas Günther,Alexis Robitaille,Hannes Roggenkamp,Henning Büttner,Daniela Indenbirken,Martin Christner,Marc Lütgehetmann,Johannes Knobloch,Martin Aepfelbacher,Adam Grundhoff,Nicole Fischer

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

While epidemiologic analysis is critical for immediate containment of HA SARS-CoV-2 outbreaks, integration of genomic surveillance revealed weaknesses in identifying staff contacts. Our study underscores the importance of high testing frequency and genomic surveillance to detect, contain and prevent SARS-CoV-2-associated infections in healthcare settings.

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SARS-CoV-2 whole-genome sequencing,containment measurements,hospital surveillance,integration of spatial and temporal information,molecular epidemiology

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