Hydroxy-safflower yellow A composites: An effective strategy to enhance anti-myocardial ischemia by improving intestinal permeability

A novel composites (SNAC-HSYA-EPO) containing Hydroxy-safflower yellow A (HSYA) was prepared by rotary evaporation. Compared with oral HSYA in SD rats, the oral composites can improve the HSYA of SNAC-HSYA-EPO in intestinal membrane transport, which weaken the efflux mechanism with EPO and SNAC, and improve the therapeutic effect of HYSA on Myocardial ischemia by anti-cardiomyocyte apoptosis and anti-inflammatory effect.