Advanced triboelectric nanogenerator-driven drug delivery systems for targeted therapies

In the current decade, remarkable efforts have been made to develop a self-regulated, on-demand and controlled release drug delivery system driven by triboelectric nanogenerators (TENGs). TENGs have great potential to convert biomechanical energy into electricity and are suitable candidates for self-powered drug delivery systems (DDSs) with exciting features such as small size, easy fabrication, biocompatible, high power output and economical. This review exclusively explains the development and implementation process of TENG-mediated, self-regulated, on-demand and targeted DDSs. It also highlights the recently used TENG-driven DDSs for cancer therapy, infected wounds healing, tissue regeneration and many other chronic disorders. Moreover, it summarises the crucial challenges that are needed to be addressed for their universal applications. Finally, a roadmap to advance the TENG-based drug delivery system developments is depicted for the targeted therapies and personalised healthcare. Graphical abstract