Survival Outcomes and Treatment Patterns in Patients With NFE2L2 and/or KEAP1 Mutation-Positive Advanced Squamous Cell NSCLC Using a Real-World Clinico-Genomic Database

Yanyu Wu,Yu Yin,Victoria Crossland,Sylvie Vincent,Paul K Paik,Neil Lineberry,Douglas V Faller

Clinical Lung Cancer（2022）

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摘要

Patients with advanced squamous cell NSCLC with a NFE2L2 and/or KEAP1 mutation have poor real-world survival, highlighting the need for a genotype-directed therapeutic strategy in this population.

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关键词

Kelch-like ECH-associated protein 1 gene mutation,Non-small cell lung cancer,Nuclear factor erythroid 2 like 2 gene mutation,PD-1/PD-L1 therapy,Retrospective

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