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A tumor-specific mechanism of T reg enrichment mediated by the integrin αvβ8

Robert I. Seed,Kenji Kobayashi,Saburo Ito,Naoki Takasaka,Anthony Cormier,Jillian M. Jespersen,Jean Publicover,Suprita Trilok,Alexis J. Combes,Nayvin W. Chew, Jocelyne Chapman,Matthew F. Krummel,Jianlong Lou,James Marks,Yifan Cheng,Jody L. Baron,Stephen L. Nishimura

Science Immunology（2021）

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摘要
Tumor cells expressing integrin αvβ8 activated latent TGF-β on T cells, inducing T reg enrichment and tumor immunosuppression.
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